HypOxygen at AACR Meeting

Our American distributors, HypOxygen, are exhibiting Whitley Workstations at this year’s AACR meeting in Philadelphia. Go over to their stand to see the i2 Instrument Workstation (specifically designed to house a Seahorse XF Analyzer in physiologically relevant conditions), H35 Hypoxystation and also to learn about our range of HEPA workstations.

EK, BKF at AACR2Pictured here is Evan Kitsell, Design Director at Don Whitley Scientific Ltd, and Dr Burga Kalz Fuller, Product Manager at HypOxygen. They will be available to demonstrate the workstations and answer any questions you may have.

As the AACR‘s website describes: this year’s meeting will “highlight the latest, most exciting discoveries in every area of cancer research and will provide a unique opportunity for investigators from all over the world to meet, interact, and share their insights. This year’s meeting theme – Bringing Cancer Discoveries to Patients – underscores the vital and inextricable link between discovery and treatment, and it reinforces the fact that research underpins all the progress we are making in the field toward cancer cures.”

 

 

 

i2 and H35 HEPA at ICR London

Whitley i2 Instrument Workstation used in deciphering the metabolic properties of Breast Cancer

The Institute of Cancer Research, London, is Europe’s largest cancer centre and one of the world’s most influential research institutes, with an outstanding record of achievement dating back more than 100 years.

Staff at the ICR with their new Whitley Workstations
ICR staff with their i2 and H35 HEPA Workstations

Cancer cells display unique alterations in their signalling and metabolic circuitry in order to fuel their growth and proliferation and/or adapt to conditions of oxygen and nutrient deprivation. The Signalling and Cancer Metabolism Team, led by Dr George Poulogiannis uses high-throughput technologies including mass spectrometry-based metabolomics, and utilizes the Seahorse XF Analyzer to measure the basal oxygen consumption and glycolysis rates in order to reveal the metabolic dependencies of breast cancer-driven alterations. We are using a Whitley i2 Instrument Workstation to study the signalling and metabolic pathways that may preserve breast cancer cell viability under hypoxia. In addition to this, we have a general interest in identifying what signalling and metabolic pathways are associated with the acquisition of microsatellite (MSI) and chromosomal instability (CIN) under oxygen deprivation conditions. Finally, we are studying the role of hypoxia in cell invasion and metastasis, oncogene-induced senescence and resistance to current treatment options.

George Poulogiannis
Team Leader
Division of Cancer Biology
Institute of Cancer Research, London

New Hypoxystation Videos

Hot on the heels of the Oscars, we go behind the scenes in science!

Earlier this week, we filmed the latest in our series of short videos about the research that is being conducted in our Hypoxic workstations. We went to visit Dr Ayse Latif from the Faculty of Medical and Human Sciences, University of Manchester, and Dr Michael Cross from the Department of Molecular and Clinical Pharmacology, University of Liverpool.

Both Dr Latif and Dr Cross use Whitley H35 HEPA Hypoxystations in their work, and Dr Latif also uses a Whitley i2 Instrument Workstation housing a Seahorse XFe96 Analyzer. These videos will be uploaded to our website shortly.

Dr Cross spoke about his study of endothelial cells, the long-term incubation of multicellular cardiac spheroids and ischaemia in the human heart. Dr Latif discussed her work in exploiting tumour cell metabolism in order to improve treatment for gynaecological cancer patients.

Click here to have a look at our earlier video with Dr Violaine See.

 

 

HEPA Filtered Hypoxystation for New Year Launch

Whitley H35 HEPA Hypoxystation

If you need to work in a HEPA filtered workstation environment – with precise control of oxygen, carbon dioxide, temperature and humidity, for example in stem cell research – this Hypoxystation is for you.

A new Hypoxystation complete with a HEPA filtration system is due to launch in the New Year. Early test results have indicated that the Whitley H35 HEPA Hypoxystation will achieve Class 2 conditions as per the redefined ISO standards for particulate count and classification for air cleanliness – this will be independently verified in due course.

The H35 HEPA Hypoxystation will look exactly like the current H35 but will be deeper by 90mm. The dimensions will therefore be 1255 x 810 x 710mm (w x d x h). This product will have a removable front as standard, fitted with two oval, sleeved ports. CO2 monitoring will be included as standard on this product, a saving of over £2,000.

Options/accessories, literature and specification details will be published on www.meintrup-dws.de in January 2014.

For further information please contact your sales representative or email us on sales@meintrup-dws.de